Sous chef Jon Bignelli, left, prepares tasting plates and main dishes with chefs Samantha Henderson, center and Christopher Christous at WD-50.

WD-50: Housed in a former bodega on a slightly scruffy street on the Lower East Side, this restaurant draws serious foodies hungry for chef-owner Wylie Dufresne's playful, cutting-edge interpretations of classic dishes. You'll never think of eggs Benedict the same way after trying Dufresne's... Tom Starkweather/Bloomberg via Getty Images