The book will be called "Enough: Our Fight to Keep America Safe from Gun Violence."
Giffords was an Arizona congresswoman who was shot in the head during a 2011 attack on a public meeting she was holding with constituents at a Tucson mall. Giffords was among 13 injured; six people were killed, including a 9-year-old girl.
Giffords and Kelly, a retired Navy captain and astronaut, previously cowrote the book "Gabby: A Story of Courage, Love and Resilience" about their relationship and her recovery. They have also been active gun-control advocates, founding the organization Americans for Responsible Solutions.
In a release from Scribner, Kelly explained that another attack prompted this new book. " 'Enough' was one of the first words Gabby said to me after we learned about the Newtown, Conn., massacre," he said. "As 2nd Amendment supporters and gun owners ourselves, we hope our book rouses the long-overdue conversation our country needs to make responsible changes to our gun laws so that no more precious lives are lost."
"Enough" will be published in June.