The drivers of the vehicles that struck him did not stop.
Troopers from the Golden Ring Barrack responded to the highway at Pleasant Hill Road about 11:36 p.m. for reports of a man having jumped from the overpass into oncoming traffic and found Ronnie Sherrod Lewis, 43, fatally injured, police said.
Lewis was pronounced dead at the scene, police said.
Witnesses told police that Lewis had jumped from the bridge and was struck by multiple vehicles, but that the drivers of those vehicles did not stop.
"The vehicles that struck the body left the scene and have not been identified at this time," police said in a statement. "Vehicle parts were located on the scene and were recovered as evidence."
The interstate was closed for a half-hour between Owings Mills Boulevard and Franklin Boulevard, police said.
Anyone with information about the incident is asked to call state police at 410-780-2700.