Jerrelle Benimon scored 21 points and pulled down 17 rebounds, and teammate Marcus Damas added 15 points as visiting
DeShawn Painter had 20 points and Dimitri Batten had 15 points for the Monarchs, who also got 13 points and 10 boards from Richard Ross.
Old Dominion (2-18, 0-8 CAA), which trailed 40-26 at halftime, came back to take the lead at 53-52 with 6:54 left in the game on a basket by Batten.
Towson (11-12, 6-4) battled back and took a 64-59 lead with 1:10 left in the game with two free throws by Damas.
Benimon hit two free throws with 40 seconds left to give the Tigers a 66-61 lead.
"He has carried us at times this year," Towson coach Pat Skerry said of Benimon.
But Painter hit a 3-pointer with 30 seconds left to cut the lead to 66-64.
Jerome Hairston made one free throw with 28 seconds left to make the score 67-64, and Batten missed a layup with 13 seconds to go.
Benimon made a free throw to make it 68-64 with 11 seconds to play, and Painter scored in the closing seconds for the final margin.
Rafael Guthrie had 14 points and Bilal Dixon had 10 rebounds for Towson.
Towson jumped out to a 16-8 lead as ODU missed 10 of its first 14 shots from the field.
The Tigers made six of 10 3-point shots in the first half.
Benimon began this week fourth in the nation in rebounds at 11.2 per game and as of Jan. 27 was tied with
Lehigh 71, Navy 49: The visiting
The win allowed Lehigh to maintain at least a share of first place in the Patriot League.
The Mountain Hawks were led by Stefan Cvrkalj's 18 points, 15 on 3-pointers. Holden Greiner had a doubledouble for the Mountain Hawks, contributing 12 points and 10 rebounds.
Will Kelly had a doubledouble for the Midshipmen (7-15, 1-5), with 11 points and 10 rebounds, while Worth Smith added 11 points.
UMBC 61, Binghamton 58: In a matchup of two struggling teams, the visiting Retrievers (5-16, 3-5 America East) held on to win.
Jordan Reed led the Bearcats (3-18, 1-7) with a game-high 21 points and seven rebounds, and Jimmy Gray added 11 points and six assists. Brian Neller led the Retrievers with 18 points, all on 3-pointers, while Chase Plummer added 17 points and 10 rebounds.
Virginia State 78, Bowie State 69: Ray Gatling scored 16 points, but the host Bulldogs (8-11, 4-6 Central Intercollegiate Athletic Association) lost to the Trojans (10-9, 5-5).
Goucher 63, Susquehanna 56, OT: The host Gophers (5-8, 3-0 Landmark Conference) outscored the Crusaders (5-9, 1-2) in overtime 12-5.
Richard Harris had a game-high 26 points for Goucher.
Hood 64, Lebanon Valley 53: Cameron Cook (Calvert Hall) scored 15 points to lead the visiting Blazers (11-9, 5-8 Commonwealth Conference) past the Dutchmen (7-13, 4-9).
St. Mary's 74, Wesley 63: Devin Spencer (Towson Catholic) scored a game-high 25 points to power the host Seahawks (19-2, 7-1 Capital Athletic Conference) past the Wolverines (16-5, 6-2).
Stevenson 77, Widener 71: Alfonzo Hawksin scored 24 points to lead the host Mustangs (12-8, 5-8 Middle Atlantic Conference) past the Pioneers (5-15, 4-9).
Mary Washington 74, Salisbury 49: Travon Vann and Elijah Gore each scored 10 points, but the visiting
Navy 72, Lehigh 47: After connecting on 14 3-pointers and shooting 50 percent from the field, the visiting Mids (12-9, 5-1 Patriot League) upended the Mountain Hawks (10-11, 2-4), who have lost three straight.
Binghamton 66, UMBC 57: The host Retrievers (6-15, 2-6) have lost two straight.
Bowie State 75, Virginia State 66: The host Bulldogs (6-12, 3-7 Central Intercollegiate Athletic Association) took control early and never let it go.
Bria Robinson had a game-high 18 points for Bowie.
St. Mary's 70, Wesley 55: The host Seahawks (9-9, 3-5 Capital Athletic Conference) outscored the Wolverines (3-16, 0-8) in the second half 34-22. Taylor Petrisko had a game-high 19 points for St. Mary's.
The Seahawks ended a three-game losing streak.
Lebanon Valley 77, Hood 53: Dyanna Prater scored a season-high 23 points in a losing effort for the visiting Blazers (5-13, 3-10 Commonwealth Conference).
Hood has lost nine of its past 10 games.
Mary Washington 55, Salisbury 39: Katie McGahagan (Northeast) had 10 points and 13 rebounds, earning her seventh doubledouble of the season, but the Sea Gulls (10-9, 4-3) led 28-14 at halftime.
Widener 87, Stevenson 64: Stephanie Martinez scored 17 points, but the host Mustangs (7-11, 4-9 Middle Atlantic Conference) lost to the Pioneers (16-4, 11-2).
Widener outscored Stevenson 53-35 in the second half.
Susquehanna 55, Goucher 49: The visiting Gophers (5-14, 1-8 Landmark Conference) cut an 18-point deficit to four with a minute to go, but got no closer.
Precious Kollock had 12 points for Goucher.