| The blackjack thriller "21" is expected to top the movie box-office charts this weekend. These figures are Times' predictions only. Studios will issue weekend estimates Sunday and final results Monday. Along with the movies listed below, contenders to make the top 10 include "Under the Same Moon," "Never Back Down" and "College Road Trip." |
| Movie (studio) | 3-day prediction (millions) | Through the weekend | Weeks |
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| 1 | 21 (Sony) | $25.0 | $25.0 | 1 |
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| 2 | Horton Hears a Who! (20th Century Fox) | 15.5 | 115.7 | 3 |
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| 3 | Superhero Movie (MGM) | 12.5 | 12.5 | 1 |
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| 4 | Meet the Browns (Lions Gate) | 10.0 | 35.6 | 2 |
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| 5 | Drillbit Taylor (Paramount) | 5.5 | 20.3 | 2 |
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| 6 | Stop-Loss (Paramount) | 4.5 | 4.5 | 1 |
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| 7 | 10,000 BC (Warner Bros. ) | 4.5 | 84.6 | 4 |
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| 8 | Shutter (20th Century Fox) | 4.5 | 19.5 | 2 |
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| 9 | Run, Fat Boy, Run (Picturehouse) | 4.0 | 4.0 | 1 |
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| 10 | The Bank Job (Lions Gate) | 3.0 | 24.3 | 4 |