| "Iron Man" is likely to dominate the second weekend of Hollywood's summer, while "Speed Racer" could face a fight from "What Happens in Vegas" for No. 2. These figures are The Times' predictions. Studios will issue weekend estimated grosses Sunday and final results Monday. |
| Movie (studio) | 3-day prediction (millions) | Through the weekend | Weeks |
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| 1 | Iron Man (Paramount) | $48.5 | $175.6 | 2 |
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| 2 | Speed Racer (Warner Bros.) | 27.0 | 27.0 | 1 |
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| 3 | What Happens in Vegas (20th Century Fox) | 21.0 | 21.0 | 1 |
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| 4 | Made of Honor (Sony) | 8.6 | 27.3 | 2 |
|
| 5 | Baby Mama (Universal) | 6.0 | 40.6 | 3 |
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| 6 | Forgetting Sarah Marshall (Universal) | 3.8 | 50.8 | 4 |
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| 7 | Harold & Kumar Escape From Guantanamo Bay (Warner Bros.) | 3.1 | 30.7 | 3 |
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| 8 | Redbelt (Sony Pictures Classics) | 2.5 | 2.6 | 2 |
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| 9 | The Forbidden Kingdom (Lionsgate/Weinstein) | 2.2 | 48.3 | 4 |
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| 10 | Nim's Island (20th Century Fox) | 1.7 | 44.5 | 6 |