The Mediterranean-style mansion of 10,594 square feet includes a media room, a library, a gym, an office, maid's quarters, six family bedrooms and eight bathrooms in two stories. The acre-plus site contains a separate guesthouse, a swimming pool with spa, mature trees and expansive lawns.
Beatty, 75, is known for his leading roles in "Bonnie and Clyde" (1967), "Dick Tracy" (1990) and "Bulworth" (1998). He won an Oscar for directing "Reds" (1981) and received the Academy's Irving G. Thalberg Memorial Award in 2000.
Bening, 54, was nominated for Oscars for her work in "The Grifters" (1990), "American Beauty" (1999), "Being Julia" (2004) and "The Kids Are All Right" (2010).
The house, built in 1992, had been for rent last year at $27,500 a month and is still available for lease at $19,995 a month. Beatty and Bening own other property in Beverly Hills.
Kurt Rappaport of Westside Estate Agency is the listing agent.