Chris Chandler sustained a concussion in the second quarter, the third time in seven 2002 starts that Chandler has been knocked out of a game.
Chandler was staggering and visibly woozy, losing his balance twice. He was unable to communicate coherently after a hit by Carolina defensive tackle Brentson Buckner. Chandler, who completed seven of his first eight passes, left the game and did not return.
"You're always concerned for any player who gets hurt in the game, particularly with concussions," coach Dick Jauron said.
Burris could get his first NFL start Sunday night against Tampa Bay in Champaign.
Buckner was flagged for roughing the passer, a call Carolina coach John Fox disputed despite admitting he didn't see the play.
"It was not a late hit," Fox said. "Supposedly it was a body slam or he was too rough on him taking him down."
The Panthers were burned for a touchdown by Chandler on the game's second play but stayed with a game plan based on constant blitzing. They consistently got to Chandler and Burris.
Chandler, who had a concussion last season while playing for Atlanta against the Bears, has missed at least one game because of an injury every season since 1993 and has sustained concussions in each of the last three seasons.
He sprained his ankle against Detroit and sprained his neck against New England. Both times he was relieved by Jim Miller, who is on injured reserve now with knee, elbow and shoulder problems.
The Panthers, who came into the game ranked No. 1 in the NFL in sacks per pass attempt, went after Chandler with a variety of blitzes.
In one second-quarter stretch of three plays, Chandler was sacked, then hit while releasing the ball to running back Adrian Peterson for minus-5 yards, and sacked again. It added up to 22 yards in losses.
Carolina finished with two sacks each of Burris and Chandler.
"[The Panthers] deserve a lot of credit; they did a very good job," Jauron said. "The men that were supposed to pick up [the blitzes] got beat."