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Russ Ortiz allowed two hits in his first two innings for Arizona, and Marland Williams had an RBI single in the ninth inning to give the Diamondbacks a 4-3 win over the White Sox on Thursday.
Ortiz signed a four-year, $33 million free-agent contract with the Diamondbacks in the offseason.
"The only thing I was concerned about was being consistent with my mechanics, and I think they were OK," Ortiz said. "I felt aggressive on every pitch."
The 23-year-old outfielder Williams is a long shot to make the big league club out of camp this season, but Arizona manager Bob Melvin was impressed with his composure.
"For a young kid to get up in that situation, sometimes they tend to get pull happy, trying to hit the ball in a gap somewhere, or out of the ballpark," Melvin said of Williams' hit. "But we've been stressing staying inside the ball in those cases. That's exactly what he did."
Chicago left-hander Mark Buehrle, who led the AL in innings pitched last year with 245, allowed two unearned runs and five hits over three innings in his first action of the spring.
"It seemed like I overthrew the ball a little too much, but overall, three innings, 45 pitches," Buehrle said. "I felt like I could've gone longer."
Switch-hitting Alex Cintron went 3-for-3, including a towering solo homer from the left side of the plate for Arizona.
Brad Halsey, acquired from the Yankees in the Randy Johnson trade, made his Arizona debut, pitching two innings of shutout ball.
Michael Gosling, another Diamondbacks left-hander, worked two innings and gave up one earned run on two hits.
Halsey and Gosling are among a number of candidates competing for the No. 5 spot in the Diamondbacks' starting rotation.