Republican presidential nominee Donald Trump is favored to win Indiana's 11 electoral votes over Democratic candidate Hillary Clinton, but races for governor and U.S. Senate are expected to be close.
In addition to the contentious presidential race, voters will decide who will replace Republican Gov. Mike Pence, who is the vice presidential candidate on the national ballot. Democrat John Gregg is facing off against Lt. Gov. Eric Holcomb.
In the U.S. Senate race, Democrat Evan Bayh is trying to return to the Senate seat he gave up six years ago citing Washington partisanship and gridlock. He is battling Republican Congressman Todd Young for the seat being vacated by Sen. Dan Coats.
It was a quick trip to the voting booth for Trump's running mate on Tuesday.
Pence was joined by his wife, Karen, as they voted in Indianapolis. The couple encountered no lines and spent about five minutes filling out their ballots.
Pence told a small crowd afterward that he was grateful for the "support and prayers of people all across the United States" and he pledged a more prosperous America with the Trump-Pence ticket.
The Republican governor and his wife voted in a precinct that has leaned liberal in past elections.
Indiana has drawn extra attention with Pence on the ticket and a record number of at least 880,000 Indiana ballots were cast before Tuesday.
Among them was Sandy Shoff, a retired principal from South Bend, who says she voted Monday for Trump even though she isn't an enthusiastic supporter. She says she likes that he speaks for the people and she's ready for a major change. She also says she doesn't like corruption in government.
Ester Escobedo, another retiree from South Bend, says she had a special feeling casting a vote for on Monday for Clinton, who could be the first woman president.
Kim Morton, a 44-year-old stay-at-home mother from South Bend who usually leans Republican, says she couldn't vote for Trump because of his negative comments during the campaign.
Polls opened at 6 a.m. and election officials are urging Indiana residents to double-check their assigned polling site before they head out to vote.
Voters can verify their polling location at indianavoters.com by entering their county of residence, their name and date of birth. That website also allows voters to look up the candidate who will appear on their ballot.
Indiana law requires voters to display government-issued photo identification before they can vote.