Gyllenhaal has acted on stage in London, but this would be his U.S. stage debut. Organizers said Thursday that the play is scheduled to open Sept. 20 at the Laura Pels Theatre in New York.
A summary of the play provided by the Roundabout states that the story revolves around a 15-year-old girl with a weight problem. Gyllenhaal will play the girl's uncle, a drifter who arrives at her home unannounced and forms an unlikely friendship.
The rest of the cast will be announced later, said the Roundabout. The play will be directed by Michael Longhurst.
Gyllenhaal starred in a 2002 London stage production of