Microsoft's video game console, which has been No. 1 in the U.S. since 2010, sold 750,000 units last week, the company said.
Nintendo, by contrast, sold 400,000 Wii U's, a figure that was in part constrained by limited supply. The Japanese gaming giant also sold 300,000 units of the original Wii, which debuted in 2006.
The Xbox 360 has climbed to the top of the sales charts and stayed there through a combination of must-have titles for hard-core gamers, such as the recently released "Halo 4," and digital entertainment options for a general audience, including streaming movies, television shows and music.
A new Xbox 360 can be bought for $200, while the Wii U starts at $300 and the original Wii is as cheap as $160.
Microsoft also claimed that its "Halo 4" game, which debuted Nov. 6, has been a hit, but the company did not provide specific data to back up that claim.
"'Halo 4' exceeded expectations with impressive sales the week of Black Friday," a Microsoft spokeswoman wrote in an e-mail.