Griffin, who has won two Emmys herself, will be hosting the 41st Daytime Emmys show from the ballroom of the Beverly Hilton Hotel on June 22.
In a statement, Griffin said, "I can only hope that at the end of the evening, critics and fans alike will compare it to the experience they once had watching Neil Armstrong take man's first step on the moon. My only regret is knowing that this epic evening will distract millions of viewers from enjoying this year's World Cup. I apologize to FIFA."
Earlier this year, Griffin won a Grammy award for comedy album, and her 20 stand-up specials have earned her a place in the Guinness Book of World Records.
This is the first year the Daytime Emmys will be livestreamed only. For the last two years, they were broadcast on