Cyrus, 21, is said to have been in Sweden at the time.
The "Wrecking Ball" singer's assistant discovered something was amiss when she returned to the Los Angeles abode around midnight Saturday and called the police, according to TMZ.
"The suspects were able to gain access into the residence and garage," the LAPD told Us Magazine in a statement. "They removed property including jewelry and a 2014 white, four-door Maserati Quattroporte. No one was home at the time of the burglary."
Police told TMZ there was no sign of forced entry. The Maserati has been estimated at $102,000 by TMZ and $135,000 by Us but no dollar amount has been attached to the jewelry.
It's the second break-in at the singer's San Fernando Valley home; last November, someone also gained entry while she wasn't home.
On Sunday, the "Hanna Montana" alum tweeted that she was feeling "homesick" just after posting that she was pretty emotional.
"ya know when you just cry in the shower for no reason," she wrote.