The role: Michael Clayton, an attorney with a conscience, who breaks down the corruption surrounding a chemical scandal.
The final pick: George Clooney. To this day, Washington regrets turning down the role. "With 'Clayton,' it was the best material I had read in a long time, but I was nervous about a first-time director, and I was wrong," Washington said.
Chris Pizzello / Invision / Associated Press; Myles Aronowitz