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Comedy writer Will Reiser was best friends with then-rising TV star Seth Rogen when he learned he had cancer in his 20s. Luckily, the writer survived and turned the experience into a screenplay. In the film, Joseph Gordon-Levitt (left) plays the twentysomething with cancer and Rogen plays the best friend. Oscar nominee Anna Kendrick plays the fumbling therapist who may capture his heart in this comedy drama.