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'Cats & Dogs' | 2001
The purr-formance: In the first of two films, the main bad cat (Mr. Tinkles) is voiced by Sean Hayes in all his take-over-the-world glory -- a quintessentially evil cat that not only wants to dominate the war against the dogs but the whole planet. In the 2010 sequel "Cats & Dogs: The Revenge of Kitty Galore," the heroic cat agent Catherine is voiced by Christina Applegate while the villainous Kitty Galore is voiced by Bette Midler.
The cats meow: The cats, whether good or bad, rely on stealth and smarts (like two of Mr. Tinkle's hitcats, the Russian and ninja Devon Rex) in their war against the dogs, while the dogs are mostly organized and usually physically superior. Just like in real life.