Baldwin will host "Up Late w/ Alec Baldwin" on Friday nights on the cable news channel starting in October, the network announced Thursday.
The show is expected to cover culture and current events, much the same way Baldwin has covered those topics in his radio show and podcast, "Here's the Thing," which has aired on public radio in New York since 2011.
In a statement, Baldwin said, "After two seasons of my WNYC podcast, I've developed a fondness for hosting a show that involved talking with smart, talented, and engaging people in every imaginable field. I'm grateful to MSNBC for helping me bring a similar show to television."
Baldwin's absence from TV hasn't been very long at all. His seven season run on NBC's "30 Rock" came to an end in May.
Baldwin tried out as an MSNBC host briefly last year when he sat in the anchor chair for a broadcast of "Last Word With Lawrence O'Donnell."