Like her costar Jason Biggs, Natasha Lyonne also starred in the teen sex comedy "American Pie" (1999), as wise-cracking Jessica. Her acting career began at the age of 6, when she played Opal on "Pee-wee's Playhouse" (1986). From there she went on to a role in Woody Allen's "Everyone Says I Love You" (1996) as Goldie Hawn's daughter. The actress then turned to indie films, where she earned lead roles in the motion pictures "Slums of Beverly Hills" (1998) and "But I'm a Cheerleader" (1999), pictured above left. Her television credits include guest appearances on "Will & Grace" (2000), "New Girl" (2011) and "Weeds" (2012). In "Orange Is the New Black," Lyonne plays a wacky-haired former drug addict.
Mark Lipson / Lionsgate; Ursula Coyote / Netflix
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