The pilot is the first project under FX Productions' recently announced deal with Louis C.K. and his production company, Pig Newton.
The show revolves a man who can explain how a nuclear reactor works, but is clueless about life. Kaufman will write and direct the pilot and serve as executive producer.
The announcements came during at the Television Critics Assn.'s winter media tour in Pasadena.
FX Productions now has 12 comedy pilots in production.