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Megan Mullaly | Karen Walker

By the time she won the role of pill-popping, sharp-tongued socialite Karen Walker on "Will & Grace," Megan Mullally had already appeared in dozens of TV series as well as in the mid-'90s Broadway revivals of "Grease" and "How to Succeed in Business." After making her indelible mark on "Will... Chris Haston / NBC
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