Debra Messing | Grace Adler
( Chris Haston / NBC / July 5, 2012 )
Although she starred in several short-lived TV series before "Will & Grace" (and guested on"Seinfeld"), Messing became a TV star via her role as neurotic but lovable interior decorator Grace Adler, the center of a close-knit social circle that included two gay men (Will and Jack) and a crazy socialite (Karen).
Messing appeared in several movies and TV shows post-"Will & Grace," most notably "The Starter Wife," a 2007 USA miniseries that nabbed Messing an Emmy nomination and that was spun off into a full series. Last year, she returned to NBC prime time as the star of "Smash," playing a brilliant, adulterous, shawl-wearing Broadway lyricist -- not to mention the best friend to her gay composer partner-in-crime, played by Christian Borle.