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Debra Messing | Grace Adler

Although she starred in several short-lived TV series before "Will & Grace" (and guested on"Seinfeld"), Messing became a TV star via her role as neurotic but lovable interior decorator Grace Adler, the center of a close-knit social circle that included two gay men (Will and Jack) and a crazy socialite (Karen).

Messing appeared in several movies and TV shows post-"Will & Grace," most notably "The Starter Wife," a 2007 USA miniseries that nabbed Messing an Emmy nomination and that was spun off into a full series. Last year, she returned to NBC prime time as the star of "Smash," playing a brilliant, adulterous, shawl-wearing Broadway lyricist -- not to mention the best friend to her gay composer partner-in-crime, played by Christian Borle.

Chris Haston / NBC
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