And with his visit will come the inevitable road closures and traffic jams.
After traveling here from Denver, Biden stopped in Beverly Hills on Tuesday night.
On Wednesday, Biden and Los Angeles Mayor
During his speech -- which will be streamed online live -- Biden is expected to advocate for enhanced overtime protections for workers, according to the White House.
He'll return to Beverly Hills on Wednesday night to attend an event for the Democratic Senatorial Campaign Committee at the Beverly Wilshire Hotel, the White House said.
On Thursday, Biden will fly to San Francisco to visit a manufacturing facility for Theranos, a health technology company.
Here's a full list of expected road closures from the Los Angeles Police Department:
Wilshire Boulevard between Beverly Drive and Santa Monica Boulevard from 11 a.m. to 1 p.m.
Wilshire Boulevard between San Vicente and Santa Monica boulevards from 11 a.m. to 3 p.m.
Laurel Canyon Boulevard between Moorpark and Vanowen streets from 12 p.m. to 3 p.m.
Tujunga Avenue between Sherman Way and Vanowen Street from 12:45 p.m. to 2:15 p.m.
Wilshire Boulevard between Beverly Drive and Santa Monica Boulevard from 2 p.m. to 4 p.m.
Wilshire Boulevard between Santa Monica Boulevard and Beverly Drive from 9 a.m. to 11 a.m.
Santa Monica Boulevard between Sawtelle and Wilshire boulevards from 9 a.m. to 11 a.m.
Sepulveda Boulevard between Lincoln and Century boulevards from 9:30 a.m. to 11:30 a.m.
For breaking news in California, follow @MattHjourno.