Police were called to the 3400 block of Manitou Avenue in Lincoln Heights after a woman reported that a relative had stabbed himself, LAPD Officer Mike Lopez said.
Officers arrived about 4:30 p.m. and found the man holding a large knife, Lopez said.
Officers told the man to drop the knife, but he continued advancing toward them. Police opened fire, Lopez said.
The man was taken to a hospital, where he was pronounced dead. Police did not release the name of the man but said his family had been notified of his death.
It's unclear how many officers opened fire or how many times he was shot.