Mrs. Griffin would have celebrated her 80th birthday in two weeks, family members said.
The daughter of an insurance executive and a homemaker, Virginia Hardesty was born in Baltimore and raised in Bolton Hill.
Mrs. Griffin worked for 39 years for Baltimore County in its Medical Adult Day Care Licensure until retiring in 2010.
"She traveled throughout the county where she was responsible for reviewing adult day care centers," said her son, J. Clarke Griffin Jr. of Baltimore.
Mrs. Griffin, who formerly lived in Homeland and Roland Park before moving to the Towson condominium in 2001, volunteered at Union Memorial Hospital.
She enjoyed playing a weekly bridge game and completing New York Times crossword puzzles.
Her husband of 46 years, J. Clarke Griffin Sr., a lawyer, died in 2000.
Mrs. Griffin had been a longtime member of Roland Park Presbyterian Church.
A memorial service will be held at 2 p.m. Nov. 3 at the Presbyterian Home of Maryland, 400 Georgia Court, Towson.
In addition to her son, Mrs. Griffin is survived by a daughter, Anne Griffin Sunderland of Timonium; three grandchildren; and two step-grandchildren.