The King of Pop Michael Jackson has died after suffering from cardiac arrest at his home in Los Angeles Thursday, the superstar's family confirmed.

Jackson, 50, was rushed to UCLA Medical Center by ambulance after a member of his staff called 911 at around 3:26 PM EST. Los Angeles Fire Department Captain Steve Ruda said paramedics performed CPR on an unresponsive Jackson. Paramedics worked to resuscitate Jackson for 42 minutes, CBS News reported.

The pop singer was pronounced dead by doctors in the UCLA emergency room at 5:26 PM EST, according to brother Jermaine Jackson who held a brief press conference outside the hospital.

PHOTOS: KING OF POP MICHAEL JACKSON THROUGH THE YEARS

Jackson's mother, Katherine, arrived at UCLA around 5:30 PM EST. Jackson's father, Joe, who is in Las Vegas, told reporters earlier that son was "not doing well."

A source told TMZ that when Jackson was pronounced dead, his sister La Toya ran into the hospital crying.

A slew of media outlets have now surrounded the hospital, with news helicopters flying over head and traffic being redirected in all directions.

An autopsy has been scheduled for Friday.

Jackson was born in Gary, Indiana on August 29, 1958 to a working class family and is the seventh of nine children - Rebbie, Jackie, Tito, Jermaine, La Toya, Marlon, Randy and Janet. His father, Joe, had been a guitarist but gave up his career in music following his marriage to his wife Katherine.

Jackson began his career in music at the early age of 5 as the lead singer of the group Jackson 5, in which he performed alongside brothers Jackie, Jermaine, Tito, Marlon. When he launched his solo career in 1971, he still remained loyal to his family and performed with the group.

PHOTOS: KING OF POP MICHAEL JACKSON THROUGH THE YEARS

In the early 1980s, Jackson became a prominent figure in pop music with the release of such hits as "Beat It," "Billie Jean" and "Thriller," which is credited with transforming the art of music videos. Videos such as "Black or White" and "Scream" also made Jackson an enduring staple on MTV in the 1990s.

Jackson is credited with popularizing a number of dance moves, including the robot and moonwalk. His distinctive musical sound and vocal style helped to influence modern day hip hop, pop and contemporary R&B artists.

Five of his solo studio albums have become some of the world's best-selling records: Off the Wall (1979), Thriller (1982), Bad (1987), Dangerous (1991) and HIStory (1995).

Jackson is one of the few artists to have been inducted into the Rock and Roll Hall of Fame twice. His other achievements include multiple Guinness World Records - including one for "Most Successful Entertainer of All Time" - 13 Grammy Awards, 13 number one singles in his solo career -- more than any other male artist in the Hot 100 era -- and the sales of over 750 million albums worldwide. Cited as one of the world's most famous men, Jackson's highly publicized personal life, coupled with his successful career, has made him a part of popular culture for almost four decades.

PHOTOS: KING OF POP MICHAEL JACKSON THROUGH THE YEARS

In 1994, Jackson and Lisa Marie Presley, the daughter of Elvis Presley, tied the knot in a marriage that lasted less than two years. In 1996, he married nurse Debbie Rowe. The couple had a son Prince Michael and a daughter, Paris Katherine. The two later divorced in 1999.

Around February 2002 Jackson had another son, Prince Michael II, also called 'Blanket', with a surrogate mother whose identity has not been disclosed. In late 2002, Jackson stirred up controversy while staying in a hotel in Berlin by briefly suspending him over the edge of the railing of a balcony.

Jackson's sudden death comes as the superstar was gearing up for this comeback 50-show tour in London. He recently passed a physical with "flying colors."

Michael is survived by three children: Michael Joseph Jackson, Jr., Paris Michael Katherine Jackson and Prince "Blanket" Michael Jackson II.