EUGENE, Ore. — Marcus Mariota threw for a career-high 456 yards and four touchdowns and No. 2 Oregon handed Tennessee its first loss of the season, 59-14 on Saturday.
Freshman Johnny Mundt, who replaced ailing tight end Colt Lyerla, had five catches for 121 yards and two touchdowns for the Ducks (3-0). Josh Huff had six catches for 125 yards and a score.
Mariota, who completed 23 of 33 passes, was the first Oregon quarterback to throw for more than 400 yards in a game since Kellen Clemens in 2005. The sophomore's yardage ties for the third-most in a game in school history.
Oregon's sloppy play at the start — four penalties for 35 yards in the first quarter — helped Tennessee (2-1) take an early lead, but it was fleeting and the Ducks led 38-7 at halftime.
Justin Worley completed 13 of 25 passes for 127 yards and a touchdown for the Volunteers, who opened the season with easy home wins over Austin Peay and Western Kentucky. But Tennessee could not keep up with the speedy Ducks, who had 687 yards in total offense compared to 316 for the Vols.
Oregon was the first opponent in a tough stretch for the Volunteers and first-year Coach Butch Jones: No. 18 Florida, No. 9 Georgia, No. 13 South Carolina and No. 1 Alabama are among Tennessee's next five opponents.
After having a first-quarter touchdown wiped out by an offensive pass-interference penalty, Oregon went in front for good at 10-7 before the quarter ended, on Mariota's 16-yard pass to Mundt. Lyerla was a surprise absence, apparently because of a stomach virus.
Mariota's nine-yard touchdown run extended the lead. During the game, the sophomore became just the fourth quarterback in Oregon history to rush for more 1,000 yards in his career.
Huff was on the run when Mariota hit him and he ran untouched for a 54-yard scoring reception. Oregon went up 31-7 on Mariota's 45-yard touchdown pass to Daryle Hawkins, and the Ducks' student section taunted Tennessee with chants of "S-E-C!" and "We want 'Bama!"
Thomas added a 28-yard scoring run for the Ducks before halftime.
Mariota had collected 350 passing yards by the break. He easily extended his string of at least one touchdown in all of his 16 games for Oregon. The streak is third among active quarterbacks.