The championship game is at 7 p.m. Saturday at Johns Hopkins.
Since the CC moved to one division, the top seed has won just twice in eight tournaments — Muhlenberg in 2006 and 2009.
No. 2 DeSales (15-10) plays at No. 3 Misericordia (15-10) at 6 p.m. Wednesday.
The teams split the regular-season meetings, with each winning at home. The Bulldogs won 68-42 in the most recent meeting. Coach Fred Richter's front court was solid in that game, particularly the defensive performances of Cherelle Simmons and Colleen Gavin. Both must keep Miseri's Christine Marks under control. Marks averages 19.2 points and 10.1 rebounds per game.
The winner plays the Eastern/King's survivor in Saturday's title game. With Shante Jones no longer on Eastern's team, Meghan Nowak carried the burden against the top-seeded Monarchs.
No. 4 Moravian visits No. 1 Scranton at 7:30 p.m. Wednesday.
The Royals won both regular-season meetings, including 81-77 at Moravian on Saturday — despite 32 points and 10 rebounds from senior Jeff Cullinan.
Moravian's last tournament appearance ended with a loss to Scranton in the 2008 semifinals.
Moravian's last win in the series was Dec. 6, 2008, at Johnston Hall.
Scranton is 10-1 at home this season, 7-0 against Landmark foes.
Wednesday's winner plays the Juniata/Susquehanna survivor in Saturday's final.
No. 2 Muhlenberg (17-8) plays No. 3 Dickinson (14-11) at 6 p.m. Friday at top seed Franklin & Marshall.
The teams split the regular-season meetings, with each winning by 19 at home. This is the teams' first postseason meeting in 42 years.
The 17 wins are Muhlenberg's most in 10 years. Coach Scott McClary's club has won seven of its last eight games.
F&M plays the winner of Wednesday's Washington/Johns Hopkins play-in game on Friday. The final is at 7 p.m. Saturday.
DIVISION II REGULAR SEASON