Pavano (3-5), who was 0-3 with a 5.28 ERA in six May starts, won for the first time since April 24. He held the Royals to two runs and eight hits in his first complete game since Sept. 10, 2010, after throwing seven complete games last year. He threw 83 strikes in 112 pitches.
Cuddyer homered off Royals rookie left-hander Danny Duffy in the third. It was Cuddyer's 18th career home run against the Royals.