Angels 5, Athletics 4 (12 innings)

TURNING POINT: Chris Iannetta’s 12th-inning homer snapped the Angels’ two-game losing streak and gave them two extra-inning wins on a six-game homestand in which four games went to overtime -- the first time that’s happened since June 1975. The Angels sent the game to extra innings when Howie Kendrick beat the relay on a potential game-ending double play, allowing Mike Trout to score from third. Trout, who drove in the Angels’ first run with a third-inning double, and Albert Pujols had back-to-back singles to start the inning. Kendrick could have won the game two innings earlier but his two-out drive to the warning track in right was speared by Brandon Moss, whose leaping, backhanded catch saved two runs.

AT THE PLATE: Trout, who has hit safely in 10 of the Angels’ 15 games this season, doubled in the team’s first run in the third. Moss, the eighth-place hitter in the A’s lineup, broke open a tie score with a three-run home run with two outs in the fourth for Oakland. Trout and Pujols, who each singled with one out in the ninth, had two hits and Jed Lowrie had two doubles and a single for Oakland.

ON THE MOUND: Left-hander Tyler Skaggs, in search of his first win at Angel Stadium, made one mistake but it was a big one, giving up a two-out, three-run home run to Moss in the fourth inning. Skaggs pitched six innings, giving up seven hits and four runs. But the Angels’ maligned bullpen came up big with Kevin Jepsen, Fernando Salas, Michael Kohn, Yoslan Herrera and Joe Smith combining to hold Oakland to just one hit over the final six innings, allowing the Angels to rally for the win.

UPON FURTHER REVIEW: Iannetta was awarded first base to start the seventh when plate umpire Tim Timmons ruled he had been hit by a pitch. Oakland Manager Bob Melvin challenged the call, which the umpires reaffirmed after consulting video replays. Iannetta later scored and, an inning later, reached base again without hitting the ball when Oakland catcher Derek Norris mishandled a third strike.

CALHOUN OUT: The Angels put outfielder Kole Calhoun on the disabled list with what Manager Mike Scioscia called a bad ligament strain. Scioscia said Calhoun, who twisted an ankle after crossing first base in the 11th inning of Tuesday’s loss, could be out as long as six weeks. Calhoun, who was hitting .250 with three home runs, is the second outfielder after Josh Hamilton to go on the DL in the last week. Brennan Boesch was called up from triple-A Salt Lake to take Calhoun’s spot on the roster and got his first at-bat in the eighth inning, reaching base on an error.

UP NEXT: The Angels have Thursday off and open a three-game series at Detroit on Friday. Right-hander Jered Weaver (0-2, 5.79 ERA) will pitch in the opener. The Tigers are expected to start left-hander Drew Smyly (1-0, 0.00), who hasn’t given up a run in six innings over two relief appearances.

kevin.baxter@latimes.com