On the women's side, two-time champ
Nadal, the two-time defending champion, eased past Simone Bolelli of Italy, 6-2, 6-2. Serving for the match, Nadal hit some typically agile shots; he earned match point by racing forward to reach a drop shot, then hurrying back to hit a heavy top-spun lob over Bolelli to within inches of the corner of the court.
Nadal was giving this week's tournament more importance than usual because he had yet to win a title on the European clay-court swing.
Murray, who finished off
Those winners will meet on Friday, along with
Murray, the 2008 champ, faces
Nadal said he was particularly happy with his serve against Bolelli.
"A serve here at altitude (Madrid is 550 meters, 1,800 feet, above sea level) is very important, it cuts the options available to the return, limiting the possibility of someone breaking you," Nadal said. "If your rival serves well, they can move you out of place. My serve has worked well and it gave me options."
His next opponent will be 10th-seeded Grigor Dimitrov of Bulgaria, who beat eighth-seeded Stan Wawrinka 7-6 (5), 3-6, 6-3 for the second time in three weeks.
"Dimitrov is a very complete player, one of the best in the world," Nadal said. "He's proved he's playing at a very high level, and I hope I'll be prepared enough to compete with him tomorrow."
Ferrer rallied to win against fellow Spaniard
The top-seeded Williams beat Carla Suarez Navarro, 6-1, 6-3, and said the score was not indicative of the match.
"Playing a really good clay-courter today is not easy," Williams said. "She proved that she has an attacking game."
Williams is playing in her third tournament since clinching her sixth Australian Open title, and 19th Grand Slam singles title.
"I love Petra. She's a great girl and a great player on top of that," said Williams, who has a 5-0 record against Kvitova.
"She's improved her consistency tremendously," Sharapova said. "She got in really good shape at the end of last year, and I think that helped her. She was able to turn many defense situations into offense."