Kawhi Leonard scored 18 points,
Indiana had lost 12 straight in San Antonio and appeared headed for a baker's dozen early.
Ginobili's three-pointer with 9:46 remaining in the first half gave the Spurs a 35-22 lead. It was their largest lead, but also the start of the team's fall as the Pacers' starting five overwhelmed their counterparts.
Indiana closed the first half on a 30-18 run and opened the second half on a 12-2 run.
George's three gave the Pacers an 85-62 lead with 46.3 seconds left in the third. George finished the game four for four on threes and also had six assists.
Boris Diaw's dunk with 6 minutes left pulled San Antonio within 101-80, but Stephenson drew a foul against Diaw while making layup on the following play. His ensuing free throw gave Indiana a 104-80 lead.
Sacramento 112, at Utah 102 (OT):
Miami 103, at Minnesota 82:
Denver 103, at Philadelphia 92:
Brooklyn 90, at Milwaukee 82:
Golden State 108, at Memphis 82:
Detroit 92, at Chicago 75: