David West had 20 points and Lance Stephenson added 15. Roy Hibbert, former San Antonio guard George Hill, C.J. Watson and Luis Scola scored 12 points apiece. Hibbert and Scola also had 10 rebounds each.
Indiana had lost 12 straight in San Antonio and appeared headed for a baker's dozen early.
Ginobili's three-pointer with 9:46 remaining in the first half gave the Spurs a 35-22 lead. It was their largest lead, but also the start of the team's fall as the Pacers' starting five overwhelmed their counterparts.
Indiana closed the first half on a 30-18 run and opened the second half on a 12-2 run.
George's three gave the Pacers an 85-62 lead with 46.3 seconds left in the third. George finished the game four for four on threes and also had six assists.
Boris Diaw's dunk with 6 minutes left pulled San Antonio within 101-80, but Stephenson drew a foul against Diaw while making layup on the following play. His ensuing free throw gave Indiana a 104-80 lead.
Sacramento 112, at Utah 102 (OT): DeMarcus Cousins had 28 points and Isaiah Thomas scored 23 of his 26 points after halftime to help the Kings snap a six-game skid with an overtime victory against the Jazz.
Denver 103, at Philadelphia 92: Jordan Hamilton hit three straight three-pointers late in the fourth quarter to help the Nuggets overcome a slow start for a win over the 76ers.
Dallas 108, at Portland 106