Jefferson has scored at least 20 point in 21 of his last 24 games for the Bobcats (28-33), who equaled their combined win total from the previous two seasons.
Charlotte became the first team since the 2009-10 Knicks to play the NBA's top four teams in consecutive games. They previously lost to San Antonio, Oklahoma City and Miami on the road.
Evan Turner had 22 points for the Pacers, who lost back-to-back games for only the second time this season but still clinched a playoff berth.
Houston 101, at Orlando 89: James Harden scored 31 points, including 25 in the second half, and the Rockets dug out of a double-digit, first-half hole. Dwight Howard added 19 points and 14 rebounds in his second trip to Orlando to face his former team.
Chicago 105, at Detroit 94: D.J. Augustin scored 26 points off the bench and Joakim Noah (10 points, 11 rebounds, 11 assists) had his third triple-double of the season and second in the last three games for the Bulls.
Sacramento 117, at Milwaukee 102: Isaiah Thomas scored 25 points and the Kings opened a season-high seven-game, 12-day trip by shooting 52% from the field.
at Portland 102, Atlanta 78: The Trail Blazers made 13 three-pointers and dominated from the start.