Game 2 is Sunday.
Lee Stempniak and James Neal scored for the Penguins. Fleury made 24 saves but was helpless on the winner.
Pittsburgh star Sidney Crosby was held without a goal for the 12th straight playoff game.
at Chicago 5, Minnesota 2: Patrick Kane scored two goals for the Blackhawks in the third period, including a terrific dash through the Minnesota zone for the tiebreaking score, and Chicago beat the Wild in Game 1 of the Western Conference semifinals.
Bryan Bickell also scored twice for the Blackhawks, who have won five in a row after losing their first two playoff games. Marian Hossa had a goal and an assist as the defending Stanley Cup champions made the most of two costly high-sticking penalties on Minnesota defenseman Jonas Brodin.
The Wild showed no sign of any fatigue just two days after their dramatic 5-4 overtime win in Game 7 of their first-round series against Colorado. Playing in the second round of the postseason for the first time since 2003, Minnesota used third-period goals from Clayton Stoner and Kyle Brodziak to tie it at 2.