Arizona (13-1) was sharp after an extended break, dominating Arizona State at both ends to quickly turn its rivalry game into a runaway.
The Wildcats took control with a big early run while building a 20-point halftime lead and kept the pressure up to get their conference season off to a rousing start.
Arizona had a rare good night from the free-throw line, making 16 of 19, and shot 51% despite a sloppy second half. Brandon Ashley and Stanley Johnson scored 13 points each.
Arizona State (8-6) beat then-No. 2 Arizona in Tempe last season, but had no chance at repeating the upset after finishing with more turnovers (22) than field goals (14).
Gerry Blakes had nine points to lead the Sun Devils, who shot 32%.
At Stanford 68, No. 21 Washington 60 (OT): Rosco Allen hit a key three-pointer in overtime for the Cardinal, which won its fourth straight. Chasson Randle (24 points) made a driving layin with 2.2 seconds left in regulation to send the game to an extra period. Robert Upshaw missed a pair of free throws for Washington with 40.2 seconds remaining in OT and the Huskies failed to score a field goal in the extra five minutes.
Washington State 69, at California 66: Josh Hawkinson had 18 points and 13 rebounds for his sixth straight double-double and Jordan Railey scored 17 as the Cougars earned their first Pac-12 road win since Jan. 26, 2013. Ike Iroegbu made four free throws over the final 36 seconds and Washington State prevailed despite missing nine of its final 12 shots. Cal's Jordan Mathews missed a potential tying three-point shot at the buzzer. The Golden Bears made only one basket over the final nine minutes of the first half and trailed, 24-20, at the break.