Rondae Hollis-Jefferson had 13 points and eight rebounds, and No. 8
Arizona (13-1) was sharp after an extended break, dominating Arizona State at both ends to quickly turn its rivalry game into a runaway.
The Wildcats took control with a big early run while building a 20-point halftime lead and kept the pressure up to get their conference season off to a rousing start.
Arizona had a rare good night from the free-throw line, making 16 of 19, and shot 51% despite a sloppy second half. Brandon Ashley and Stanley Johnson scored 13 points each.
Arizona State (8-6) beat then-No. 2 Arizona in Tempe last season, but had no chance at repeating the upset after finishing with more turnovers (22) than field goals (14).
Gerry Blakes had nine points to lead the Sun Devils, who shot 32%.
At Stanford 68, No. 21