Clarkson led the D-Fenders with 35 points, shooting 16 of 23 from the field, and 11 assists.
Black, who was claimed by the Lakers off waivers from the Houston Rockets last week, had 23 points and 12 rebounds.
The Bighorns fell one point short of tying the NBA Development League's all-time scoring record, set by the D-Fenders in late December at 175.
The D-Fenders scored 98 points in the first half alone in the losing effort.
The Lakers have three affiliate players with the D-Fenders who all went through training camp but were cut before the Lakers set their roster for opening night. Roscoe Smith had 32 points and 15 rebounds for his 14th double-double of the season. Jabari Brown scored 26 while Keith Appling finished with 12 points and seven assists.
Vander Blue contributed 31 points and 10 assists for the D-Fenders.
Both Clarkson and Black were recalled by the Lakers (10-23) after the game and are expected to be in uniform on Sunday night when team hosts the Indiana Pacers (13-21).
Manny Harris, who played 20 days with the Lakers last season, recently left the D-Fenders to play overseas in Turkey. Harris was the D-League's fourth-leading scorer at 25.7 points a game.
The team has since added forward-center Jarvis Varnado, who was acquired in a trade with the Iowa Energy for first- and second-round picks in the D-League draft. Varnado was the 41st overall pick by the Miami Heat in the 2010 NBA draft and also played a stretch with the Boston Celtics.