Klay Thompson scored 22 first-quarter points, nearly matching the Lakers' total of 25, and finished with 36.
Playing without Kobe Bryant and D'Angelo Russell, the Lakers stayed relatively close in the second quarter and trailed by 15 heading into the break. Then Golden State completely took over in the third quarter.
Lou Williams hit a free throw with 8:04 left in the third, closing the Lakers to within 66-55. The Warriors went on to score the next 22 points, pulling away by 33 (88-55), until Jordan Clarkson ended the drought with a jump shot with 2:18 remaining in the quarter.
The Warriors coasted to their 33rd win in 35 games, best in the NBA. Stephen Curry scored 17 points with six assists. Draymond Green, who had notched three straight triple-doubles before visiting the Lakers, ended the night with nine points, 12 rebounds and five assists.
Marreese Speights scored 12 off the bench and Harrison Barnes had 10.
The Lakers were led by Clarkson's 23 points. Williams managed 10, failing to score a field goal (0 for 7) but making all his free throws.
Ryan Kelly scored 10 points, all well after the game was decided. Julius Randle missed seven of eight shots for two points but had nine rebounds.
Williams wasn't the only Laker to struggle with his shooting. Metta World Peace missed eight of 10 attempts, Roy Hibbert six of seven and Anthony Brown five of six.
Bryant did not play because of a lingering shoulder issue. Russell had a sore throat.
The Lakers shot just 31.9% from the field and 23.8% from three-point range (five for 21), but did hit 83.3% from the line (25 for 30).
The Warriors shot 46.5%, 43.3% (13 for 30) and 76.2% (16 for 21), respectively.