James is nursing a sore wrist, with the Cavaliers coming off a rare loss on Friday to the Indiana Pacers, their first defeat in 13 games.
The Cavaliers' 109-102 win at Staples Center on Jan. 15 was the start of a 12-game winning streak.
James is questionable, while center Anderson Varejao (Achilles') is out for the year.
The Lakers played the Cavaliers closely in L.A., but that was with a healthy Bryant scoring 19 points with 17 assists, and Hill leading the way with 20 points on 10 of 14 shooting.
The Cavaliers' big three is a lot for any team to deal with. If James is able to play, Ryan Kelly will likely draw the defensive assignment initially.
Tarik Black is a tough defender, but he'll be tested against Love, while fellow rookie Jordan Clarkson would draw Irving.
The Lakers are now focused more on player development than winning. Sunday should provide valuable minutes for the team's youth movement.
Timofey Mozgov always seems to give the Lakers fits, although he only scored four with the Cavaliers in January.
On offense, the Lakers would benefit if Nick Young could get back on track. He went scoreless on Friday night in an overtime loss to the Orlando Magic.
The Lakers aren't likely to beat the Cavaliers in Cleveland, with or without James.