The Blazers, one of the top teams in the Western Conference, are 22-5 at home. The Lakers are in 14th place in the conference, just two games ahead of the 11-41 Minnesota Timberwolves.
Chris Kaman (ankle) and Joel Freeland (shoulder) won't play for the Trail Blazers.
The Lakers have competed well in their two previous games against the Blazers this season, until Damian Lillard asserted himself in a big way in both Portland victories.
Against the Lakers, Lillard is averaging 36.5 points with six assists while shooting 56.8% from the field and 5.0% from three-point range.
Lillard is scoring 21.6 points a night on the season -- but has tortured the Lakers like no other franchise.
None may be enough against Lillard.
As great as Lillard is, Aldridge is scoring at a higher clip, 23.7 points a night, and averaging 10.3 rebounds.
Thus far the Lakers have done a solid job against the Blazers' All-Star power forward, holding him to 18.0 points, on 39.5% shooting from the field.
The Lakers aren't bad inside defensively with their core of big men, but Aldridge is still a major concern -- so much that the Lakers can't simply throw everything they have at Lillard.
The Lakers have lost 14 of 15 games. That's not going to improve on Wednesday night in Portland.