On Thursday, the Lakers lost to the Cleveland Cavaliers (20-20) at Staples Center. A quick turnaround in Utah will be a challenge, especially without Bryant.
Wayne Ellington is expected to start for the Lakers' superstar.
Both teams have lost three straight.
Hayward is a threat as a scorer (18.9 points a game) and playmaker (4.0 assists). He's shooting 45.0% from the field and 36.5% from three-point range.
Favors is at 16.2 points with 8.6 rebounds, while shooting 55.55 from the field.
The Lakers will need to focus their perimeter defenders on Haywood while the big guys deal with Favors.
Wesley Johnson may be the Lakers' best choice on Hayward, although Ellington, Nick Young and possibly Jordan Clarkson may all take turns against him.
After a difficult start to the season, point guard Trey Burke has played well in January, averaging 17.3 points and 4.7 assists a game, while shooting 42.9% from the field.
That's a jump from December, when Burke shot just 37.1%.
The Lakers need big performances from point guards Jeremy Lin and Ronnie Price, especially in the absence of Bryant.
At full strength, with Bryant and not on the second night of a back-to-back, the Lakers might be the pick.
That's not the case on Friday.