Bryant was injured on Dec. 17 in Memphis, suffering a fracture of his lateral tibial plateau in his left knee.
After missing the start of the season while recovering from an Achilles tear, Bryant got through just six games before suffering another injury.
Nevertheless, fans voted for the popular Bryant to start in the All-Star game.
Bryant' s knee injury will be evaluated after the All-Star break. The Lakers have a 18-35 record this season and are tied with Sacramento for last place in the West.
Harden was voted in as an All-Star reserve by the Western Conference coaches. Through 45 games this season, Harden is averaging 23.9 points, 5.3 assists and 4.7 rebounds.