"He's going to give it a go," said a person familiar with the situation.
Howard missed the Lakers' 111-100 victory Friday over the Minnesota Timberwolves on Friday night so he could return home for a relatively non-invasive platelet-rich plasma (PRP) treatment in his right shoulder.
Howard aggravated a torn labrum in the shoulder Wednesday against Phoenix.
"I think he's on a plane [to Detroit] in 10 minutes," Coach Mike D'Antoni said after the Lakers finished practicing Saturday at about 3 p.m. Eastern time.
Howard has sat out four games and left two others because of his shoulder. He received a series of PRP injections that were meant to stimulate healing and growth in the shoulder area.
The Lakers (21-26) are 1-1 on their seven-game "Grammy trip."