Kobe Bryant looked on pace for a triple-double with six points, six assists and seven rebounds.
The Lakers finished a strong first quarter of basketball with a four-point lead over the Oklahoma City Thunder.
Antawn Jamison hit three free throws with 1.9 seconds left in the quarter to give the Lakers their biggest lead of the game. Serge Ibaka got up gingerly after fouling Jamison, favoring what looked like his hip.
The Lakers shot 45.5% from the field with seven players scoring, led by Metta World Peace, Earl Clark and Steve Nash with five points apiece.
The Thunder hit only 38.5%, led by Kevin Durant's seven points.
Oklahoma City had seven offensive rebounds to the Lakers' five, giving them four more shot attempts in the quarter.
The Lakers (18-25) host the Oklahoma City Thunder (34-10) on Sunday afternoon at Staples Center.
The Thunder have the best record in the NBA. The Lakers finally ended a four-game losing streak with a victory on Friday over the Utah Jazz.
It would be a huge win for the Lakers but a difficult one to get against Oklahoma City.
For a more in-depth breakdown, check out Preview: Lakers at Thunder.
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Email Eric Pincus at firstname.lastname@example.org and follow him on Twitter @EricPincus.