OG Anunoby scored 16 points and James Blackmon Jr. had 14 Wednesday night, leading No. 13
The Hoosiers (5-1) have won two in a row since last week's stunning loss to Fort Wayne.
The curse of No. 3 continues. With Kansas losing on opening night, Indiana's upset last week and now the Tar Heels falling, three of the four teams ranked No. 3 this season have lost in their first appearance in that spot.
Blackmon injured his knee and Anunoby tried to play through an illness against Fort Wayne. This time, they helped Indiana start fast and fend off the Tar Heels' second-half charges to close it out, though Anunoby was injured at the end of the game and needed help to get to the locker room.
North Carolina (7-1), which trailed for a total of 16 seconds during its four-game trip to Hawaii, never led and spent most of the game trailing by double digits.
The Tar Heels were led by Justin Jackson with 21 points.
at No. 14
at No. 6 Virginia 63,
at No. 16
at No. 23
at No. 9 Baylor 79, Sam Houston State 45: The Bears remained unbeaten, jumping to a 10-0 lead as Sam Houston State missed its first 13 shots.
Omaha 83, at
USC 66, at No. 25 Texas A&M 62: Kristen Simon had 20 points and eight rebounds, Sadie Edwards scored 18 points and the Trojans (6-1) handed the Aggies (5-1) their first loss of the season. After trailing 34-27 at halftime, the Trojans took the lead with an 8-0 third-quarter run. Khaalia Hillman led Texas A&M with 21 points.