Serena and Venus Williams could meet in the third round of U.S. Open

Serena and Venus Williams could be headed toward their earliest Grand Slam meeting in 20 years, facing a potential third-round matchup at the U.S. Open.

If the sisters do play each other, the winner might face No. 1-ranked Simona Halep in the fourth round.

That is certainly the most intriguing section of the women’s and men’s brackets revealed at Thursday’s draw for the last major of the year.

This marks Serena’s return to Flushing Meadows after missing the hard-court tournament in 2017 — she gave birth to her daughter last Sept. 1.

The 36-year-old American has won six of her 23 Grand Slam titles at the U.S. Open and was given the No. 17 seed by the U.S. Tennis Assn. — nine places above her current ranking.

Venus, who won five of her seven Grand Slam singles trophies in New York, is ranked and seeded 16th. She faces a tricky first-round match against Svetlana Kuznetsova, whose two major championships include the 2004 U.S. Open.

Kuznetsova was given a wild-card entry for the tournament, where main-draw play begins Monday.

Serena’s opener comes against 60th-ranked Magda Linette of Poland. Should the Williams siblings both make it to the third round, they would play each other at a Grand Slam tournament sooner than they have since Venus beat Serena in the second round at the 1998 Australian Open — their very first head-to-head match on tour.

Serena Williams, left, speaks with her sister Venus WIlliams before their matches in a New York tournament on March 5.

(Timothy A. Clary / AFP/Getty Images)

They’ve gone on to play a total of 29 times — Serena leads 17-12 — and that includes nine all-in-the-family Grand Slam finals, most recently at the 2017 Australian Open.

In the men’s field, No. 1-ranked and defending champion Rafael Nadal opens against David Ferrer in an all-Spanish rematch of their 2013 French Open final. No. 2 Roger Federer plays Japan’s Yoshihito Nishioka in the first round.

Federer faces a potential quarterfinal against No. 6 seed Novak Djokovic, the Wimbledon champion who beat him two weeks ago in a tuneup and is considered the tournament favorite.