Chris Bosh added 20 for the Heat, including a crucial three-pointer with 1:07 left as Miami held off a late New York rally.
Carmelo Anthony also returned after a two-game absence because of back spasms to score 31 points for the Knicks.
After trailing by as many as 16, the Knicks pulled to within two, 65-63, on
Wade then followed with a baseline jumper and scored 12 of Miami's next 15 points to help the Heat maintain the lead.
However, after the Knicks again pulled to within two, 79-77, on Stoudemire's tipin with 1:23 left, Bosh hit his three-pointer and New York never got closer.
The Heat led the entire game, getting out to a 10-2 lead and never relinquishing it.
San Antonio 111, at Boston 89:
Memphis 97, at Sacramento 85:
Golden State 104, at Detroit 93:
Orlando 93, at
Chicago 102, at Brooklyn 84: