Shumpert started in the win over the Los Angeles Clippers but left in the second quarter with a sore knee and didn't return. The team said Saturday that imaging tests revealed swelling in Shumpert's knee and he will undergo treatment for a week.
Shumpert is averaging just 5.2 points and 3.3 rebounds, but he's been invaluable while filling in for Rose and Thomas.
With Shumpert out, the Cavaliers are expected to recall John Holland from their Canton G-League affiliate. He scored 43 points in a game for the Charge earlier this season.
On Friday, the Cavaliers said Rose could miss another three weeks with an ankle injury that has bothered him for a month. Thomas is still working his way back from a serious hip injury, and it's not clear when the All-Star will make his debut with Cleveland.
The Cavaliers (9-7), who have won five of six, play in Detroit on Monday.