Oklahoma freshman Samaje Perine set a major college record by running for 427 yards in a driving rainstorm, scoring five touchdowns and leading the No. 21 Sooners over Kansas, 44-7, on Saturday.
A week after Wisconsin's Melvin Gordon set the mark by rushing for 408 yards against Nebraska, Perine ran past him.
Perine broke the 7-day-old record on his 34th and final carry, a 42-yard run with 12:16 left in the fourth quarter.
Perine got off a fast start, running for a 49-yard TD on his first carry. He added TD runs of 33 and 34 yards in the second quarter and scored on runs of 66 and 27 yards in the third.
In a game that started 90 minutes late because of lightning, Perine shattered the school rushing record of 294 yards set by Greg Pruitt in 1971.
The Sooners (8-3, 5-3 Big 12) held Kansas to 103 yards to win their second straight.
The Jayhawks (3-8, 1-7) lost their 29th straight true road game and 32nd in a row straight outside of Lawrence. Kansas had hoped to build on last week's 34-30 loss to TCU, but the Jayhawks failed to produce any points on offense.
Perine carried the Sooners on an afternoon when they were minus their top passing threats.
Quarterback Trevor Knight sat out with a neck injury. Top receiver Sterling Shepard, who had been dealing with a nagging groin injury, left after a punt return in the first quarter. Tight end Blake Bell, who was second on the team with four touchdown catches, was out with a strained knee.
The injuries and the weather forced Oklahoma to depend almost entirely on its power running game.
Perine's first carry resulted in his 15th touchdown rushing, tying Adrian Peterson for Oklahoma's freshman record.
On his first carry of the second half, Perine bolted for his longest run of the season, a 66-yarder that made it 31-0.
Later in the third quarter, the crowd started chanting "Pe-rine! Pe-rine!" and he delivered. He got loose for a 27-yard touchdown run on fourth-and-2 to push the lead to 41-7.
Kansas scored when Cassius Sendish returned Keith Ford's fumble 63 yards for a touchdown.
The Sooners now have won 10 straight in the series — the Jayhawks haven't beaten Oklahoma since 1997 and haven't won in Norman since 1996.
No. 1 Alabama 48, Western Carolina 14
Derrick Henry rushed for two touchdowns and scored a third on a catch, all in the first half, to lead the Crimson Tide to the victory in Tuscaloosa, Ala.
The Crimson Tide (10-1) recovered from a slow start to score the final 31 points in its first game since rising to No. 1 in the College Football Playoff rankings. FCS member Western Carolina (7-5) trailed just 17-14 early in the second quarter.
Blake Sims completed 17 of 25 passes for 222 yards and two touchdowns, while throwing an interception in the end zone. Henry had touchdown runs of 10 and 23 yards and a 9-yard scoring reception.
Neither played in the second half.
The Tide can clinch a spot in the SEC championship game with a victory next weekend over No. 16 Auburn.
Alabama held out injured tailback T.J. Yeldon (ankle), wide receiver DeAndrew White (hamstring) and placekicker Adam Griffith, whose injury hasn't been specified.
No. 4 Mississippi State 51, Vanderbilt 0
Dak Prescott threw three touchdown passes and ran for another to lead the Bulldogs to the victory at Starkville, Miss.
It was a dominant performance by the Bulldogs (10-1, 6-1 Southeastern Conference), who finished undefeated at Davis Wade Stadium for the first time since 1999.
Prescott threw touchdown passes of 9, 27 and 14 yards and Christian Holmes ripped the ball out of Vanderbilt receiver Latevius Rayford's hands before returning it 51 yards for a touchdown as the Bulldogs built a 37-0 lead by halftime.
It was the largest halftime lead for Mississippi State against an SEC opponent in program history. The Bulldogs now have 10 wins in the regular season for the first time.
Vanderbilt (3-8, 0-7) had three turnovers in the first half. The Commodores finished with just 228 total yards, including 49 on the ground.
No. 6 Ohio State 42, Indiana 27
Jalin Marshall returned a punt 54 yards for a touchdown to give No. 6 Ohio State the lead late in the third quarter and the Buckeyes added three late insurance scores to defeat Indiana, 42-27, on Saturday.
The surprisingly tight game for most of the day could impact the playoff hopes of the Buckeyes (10-1, 7-0 in Big Ten play), who clinched the East Division title and a berth in the conference title game.
They trailed the 34-point underdogs 20-14 after Tevin Coleman sped 90 yards for a TD midway through the third quarter. A week after rushing for 307 yards, Coleman went for 228 yards on 27 carries for three scores for the Hoosiers (3-8, 0-7), who have lost six games in a row.
Marshall caught fourth-quarter scoring passes of 6, 15 and 54 yards to put the game out of reach.
The Hoosiers' last chance at a tying score ended with Tyvis Powell picking off a pass from Zander Diamont with 4:25 left, deep in Indiana territory.
Despite the up-and-down day for the Buckeyes, J.T. Barrett set the school mark for touchdown passes (33) in a season and Ezekiel Elliott, who had 107 yards on 13 carries, topped 1,000 yards. Barrett completed 25 of 35 passes for 302 yards and four scores with two interceptions, and ran for 78 yards on 20 attempts.
No. 7 Baylor 49, Oklahoma State 28
Bryce Petty threw touchdowns on Baylor's first two drives that took less than a minute combined, putting the Bears ahead to stay against the visiting Cowboys.
Playoff-contending Baylor (9-1, 6-1 Big 12) won its 15th consecutive home game on a dreary and rainy night along the banks of the Brazos River, staying in a three-way tie with No. 5 TCU and No. 12 Kansas State for the Big 12 lead with two games left.
Devin Chafin ran for 106 yards and three touchdowns, while Shock Linwood had 113 yards rushing with a score for Baylor. Corey Coleman extended his nation's best streak with a TD catch in his seventh consecutive game.
Oklahoma State (5-6, 3-5) has lost five games in a row. That is its longest losing streak since Mike Gundy's first season as head coach in 2005.
Arkansas 30, No. 8 Mississippi 0
Rohan Gaines returned an interception 100 yards for a touchdown, and Arkansas' defense forced six turnovers in the rout at Fayetteville, Ark.
The win earned the Razorbacks (6-5, 2-5 Southeastern Conference), losers of 17 straight SEC games until a win over LSU last week, bowl eligibility for the first time in three seasons.
Led by Martrell Spaight's 11 tackles, Arkansas also earned back-to-back conference shutouts for the first time since joining the SEC in 1992.
Bo Wallace led the Rebels (8-3, 4-3) with 235 yards passing, but he also threw two interceptions. Ole Miss outgained the Razorbacks 316-311 but was unable to overcome the turnovers in losing its third straight SEC game.
No. 10 Georgia 55, Charleston Southern 9
Georgia scored two touchdowns on its first three snaps, including an 83-yard touchdown run by Nick Chubb, and the Bulldogs rolled past Charleston Southern.
Hutson Mason played only the first half and threw three touchdown passes, including two to Chris Conley. Mason's 35-yard scoring pass to Conley came on Georgia's first play following a fumble recovery by Ramik Wilson. Mason added touchdown passes of 19 yards to Justin Scott-Wesley and 23 yards to Conley.
Chubb recorded his sixth straight 100-yard game, with 113 yards rushing and two touchdowns on only nine carries in the first half for Georgia (9-2). The Bulldogs, who have completed their Southeastern Conference schedule, would land in the SEC championship game if Missouri loses one of its final two games.
Charleston Southern (8-4), hoping for a spot in the FCS playoffs, was held to 211 total yards.
No. 11 Michigan State 45, Rutgers 3
Jeremy Langford and Tony Lippett celebrated senior day in style as the Spartans smashed the Scarlet Knights in East Lansing, Mich., for their 40th win in four seasons and 51st in five.
Langford, who played cornerback and wide receiver before returning to running back, rushed for 126 yards and two touchdowns. That stretched his streak of 100-yard games in conference play to 15, the longest in the Football Bowl Subdivision in the last 10 years.
Lippett, another fifth-year player who switched positions multiple times, had five catches for 72 yards and his 10th score this season. He became the eighth receiver in school history to pass the 1,000-yard mark and also played well in a surprising stint at cornerback.
The Spartans (9-2, 6-1 Big Ten) scored on five on their first six possessions and finished with a 520-234 edge in total offense, including 254 through the air from Connor Cook.
Quarterback Gary Nova threw for just 108 yards on 11-for-26 accuracy for the Scarlet Knights (6-5, 2-5), looking nothing like the player who had 404 passing yards in a win over Michigan.
No. 14 Auburn 31, Samford 7
Cameron Artis-Payne ran for 129 yards and a touchdown, quarterback Nick Marshall passed for 171 yards and a score and the Tigers snapped a two-game skid with the win over visiting Samford.
Auburn (8-3) used the game against an FCS opponent to tune up for next week's Iron Bowl showdown at No. 1 Alabama.
The Tigers, who upset Alabama last year before narrowly losing the national title game to Florida State, needed a morale boost after dropping from third to 14th in the College Football Playoff rankings with consecutive losses to Texas A&M and Georgia.
Artis-Payne, the Southeastern Conference's leading rusher, has rushed for 100-plus yards eight times this season. He averaged 5.4 yards on 24 attempts.
Samford, a Birmingham-based Southern Conference school coached by former Auburn quarterback and 1971 Heisman Trophy winner Pat Sullivan, snapped a four-game winning streak.
No. 16 Wisconsin 26, Iowa 24
Melvin Gordon surpassed 2,000 yards rushing with 200 yards and two touchdowns, and the Badgers earned te victory in Iowa City for their sixth straight win.
Gordon became the 17th FBS player with a 2,000-yard rushing season to lead the Badgers (9-2, 6-1 Big Ten). Wisconsin still has to beat Minnesota in Madison next weekend to earn a shot at Ohio State in the Big Ten title game.
Gordon's performance came just hours after Oklahoma's Samaje Perine broke his week-old FBS record with 427 yards rushing in a win over Kansas. But Gordon was sensational in his own right, cracking the 2,000-yard on an 88-yard run midway through the third quarter.
Jake Rudock had 311 yards passing and two TDs for the Hawkeyes (7-4, 4-3), who rallied from 16 down to get within 26-24 with just over 5 minutes left.
No. 20 Missouri 29, Tennessee 21
Maty Mauk threw a pair of touchdown passes and Marcus Murphy ran for two scores to lead the Tiger to the win and maintain control of the SEC East race.
The Tigers (9-2, 6-1 Southeastern Conference) set a school record with their 10th straight road win.
Missouri can clinch the East Division and earn a second straight trip to the SEC championship game by winning at home Friday over Arkansas. A loss would send No. 10 Georgia (9-2, 6-2) to Atlanta instead.
Andrew Baggett's 43-yard field goal broke a 13-all tie midway through the third quarter. Mauk threw a 73-yard touchdown pass to Jimmie Hunt and a 13-yard scoring strike to Bud Sasser in the fourth quarter.
Tennessee (5-6, 2-5) must win next week at Vanderbilt to become bowl-eligible for the first time since 2010.
No. 22 Clemson 28, Georgia State 0
Freshman Tyshon Dye rushed for 124 yards and two touchdowns as the Tigers bounced back from their loss to Georgia Tech last week with a shutout at home.
The Tigers (8-3) fell apart offensively a week ago with its lowest point total in seven years to lose to the 17th-ranked Yellow Jackets 28-6. But behind Dye's powerful runs, Clemson again got cranked up to run past the Panthers (1-10), who have lost 10 straight.
Dye's rushing yards were the highest single-game total for Clemson this season. He had touchdown runs of 3 and 6 yards in the opening quarter that put the Tigers up for good. Quarterback Cole Stoudt also rebounded after throwing three interceptions — two returned for TDs — last game. He completed 19 of 29 passes for 132 yards and an 8-yard touchdown pass to Mike Williams that closed Clemson's scoring.
No. 25 Minnesota 28, No. 23 Nebraska 24
Briean Boddy-Calhoun ripped the ball out of Nebraska receiver De'Mornay Pierson-El's hands at the Minnesota 2-yard line after Mitch Leidner scored the go-ahead touchdown, and the Gophers overcame a 14-point halftime deficit to defeat the Cornhuskers in Lincoln, Neb.
The Gophers big defensive stop kept alive their hopes in the Big Ten West. They can win the division and go to the conference championship game on Dec. 6 with a win at Wisconsin next week.
The Cornhuskers, humiliated at Wisconsin a week ago, lost back-to-back conference games for the first time since 2009.
Nebraska led 24-14 in the middle of the third quarter. But Minnesota, with running back David Cobb on the sideline with his left leg heavily wrapped, churned out a couple of long drives to take the lead.
The Huskers started their final possession with 3:25 to play and drove to the Minnesota 30. Pierson-El caught Tommy Armstrong's third-and-9 pass at the 2, but Boddy Calhoun stripped him of the ball with 1:19 left.
Minnesota ran out the clock and secured its first road win against a Top 25 opponent in 21 games since 2000. It's also the Gophers' second straight win over the Huskers and their first in Lincoln after seven straight losses since 1960.
Leidner ran 22 times for a season-high 110 yards and two touchdowns and completed 8 of 17 passes for 135 yards. Cobb had 15 runs for 80 yards and a touchdown before leaving the game in the third quarter. Nebraska's Ameer Abdullah had 98 yards and a touchdown on 20 carries. Armstrong was 12 of 19 for 233 yards.
Marshall 23, Alabama Birmingham 18
Rakeem Cato threw for two touchdowns and Ra'shawde Myers recovered a fumble in the end zone for a late score to help the Thundering Herd win in Birmingham, Ala.
Marshall (11-0, 7-0 Conference USA) had its closest game yet against the Blazers (5-6, 3-4) but took another step toward a possible New Year's Day bowl.
Marshall led 17-6 at halftime and seemed to have the game in hand after Cato's 28-yard touchdown pass to Tommy Shuler and a 43-yard scoring pass to Angelo Jean-Louis.