Carr completed 22 of 28 passes for 254 yards and completely outplayed counterpart Colin Kaepernick as the Raiders (2-11) won their second straight home game surrounding last week's 52-0 loss at St. Louis.
With a second straight loss the 49ers (7-6) are in danger of missing the playoffs for the first time in coach Jim Harbaugh's four-year tenure.
San Francisco is two games out of the second wild-card spot with three games remaining after making three straight NFC title games.
Seahawks 24, Eagles 14
Russell Wilson threw two touchdown passes, ran for another score, and Seattle stifled Philadelphia's high-powered offense to win.
Wilson had 263 yards passing and ran for 48 to help the Seahawks (9-4) win their third straight game. The defending Super Bowl champions have victories over NFC West-leading Arizona (10-3), San Francisco (7-6) and Philadelphia (9-4) in the last three weeks.
The Eagles host Dallas (9-4) with first place in the NFC East at stake next week.
Richard Sherman and Co. held the Eagles to 139 total yards, the fewest under Chip Kelly.
Pete Carroll was the winner in his first NFL matchup against Kelly. In the coaches' only other meeting, Kelly's Oregon Ducks beat Carroll and USC 47-20 on Oct. 31, 2009.
Cleveland contained the Colts quarterback until the final minute, but couldn't finish him off.
Before Luck connected with Hilton, Colts running back Daniel Herron picked up 2 yards on fourth down to keep the drive alive. Luck, who threw two interceptions and spent the day being harassed by an energized Browns defense, then fired his second TD pass to Hilton.
The Colts (9-4) trailed 21-7 in the third quarter, but stormed back behind Luck, who finished 24 of 53 for 294 yards.
The Browns (7-6) got two defensive touchdowns, but Cleveland's offense, led by struggling quarterback Brian Hoyer, couldn't do enough to keep the team's playoff hopes from fading.
In a game they had to win, the Steelers (8-5) caught up and ran away with 25 points in the fourth quarter.
For Cincinnati (8-4-1), it was a second straight lopsided loss at home loss to a division rival. The Bengals fell to Cleveland 24-3 before going on the road and winning three straight to take control of the division.
Now, it's anyone's title.
Le'Veon Bell had another big all-around game, running for 185 yards, catching six passes for 50 yards, and scoring three touchdowns.
And Roethlisberger emerged from a three-game funk by making a bunch of big plays, including the longest touchdown pass in the NFL this season.
Cardinals 17, Chiefs 14
Kerwynn Williams rushed for 100 yards two days after being elevated from the Arizona practice squad as the Cardinals snapped a two-game losing streak.
The NFC West-leading Cardinals (10-3) took the lead when Drew Stanton threw a 26-yard touchdown pass to Jaron Brown in the third quarter.
Jamaal Charles scored two first-half touchdowns on a 63-yard run and 18-yard pass from Alex Smith, but the Chiefs (7-6) were shut out in the second half.
Arizona won a crucial call reversal when it challenged that tight end Travis Kelci fumbled deep in Cardinals territory late in the fourth quarter.
Broncos 24, Bills 17
C.J. Anderson ran for three touchdowns and Denver overcame a rare unsteady outing by Peyton Manning to win.
Manning's streak of 51 straight games with a touchdown throw — three shy of Drew Brees' NFL record — ended on a sun-splashed, almost still afternoon in Denver, where the game-time temperature was a balmy 63 degrees.
Despite three turnovers, the Broncos (10-3) won their third straight game since changing from a pass-oriented attack to a run-heavy approach.
Manning finished 14 of 20 for 173 yards with two interceptions. His top receiver, Demaryius Thomas, was held to two catches for 11 yards, and tight end Julius Thomas (ankle) was active but didn't play for the third straight week.
Buffalo is 7-6.
Panthers 41, Saints 10
Cam Newton passed for three touchdowns, appeared to incite a scuffle with frustrated New Orleans after he went over the pile for another score, and Carolina ended a six-game losing streak.
Newton's jawing and “Superman” celebration of his 2-yard rushing touchdown in the first quarter drew a shove from linebacker Curtis Lofton, igniting a scrum that went from a closed gate behind the goal post and into a tunnel.
Panthers tight end Brandon Williams was ejected for punching Cam Jordan, but Carolina kept rolling.
Newton's scoring passes went to Kelvin Benjamin, Greg Olsen and Fozzy Whitaker.
New Orleans (5-8) lost its fourth straight home game to drop a half-game behind Atlanta.
Baltimore played more than 17 minutes before picking up a first down, then overcame a 10-point deficit to win.
The Ravens rallied with consecutive touchdown drives of 97 and 75 yards, and added the clinching score after a favorable replay reversal.
A gamble by coach John Harbaugh in the third quarter helped. The Ravens made a first down on fourth-and-1 in their own territory, jump-starting the TD drive that put them ahead.
The victory gave Baltimore (8-5) a significant edge over Miami (7-6) in the AFC's scramble for a wild-card playoff berth. The Dolphins, who haven't been to the postseason since 2008, are now a long shot with three games to go.
The Lions (9-4) trail first-place Green Bay by a half-game, with the Packers hosting Atlanta on Monday night.
Tampa Bay (2-11) was finally eliminated from playoff contention — the NFC South's mediocrity could only keep the Bucs in it for so long. They turned the ball over three times in the second quarter against Detroit and never led.
The Lions have won two in a row, and they figure to be favored again next weekend when they face Minnesota in their final home game of the regular season.
Eli Manning threw for 260 yards and a touchdown, and New York snapped a seven-game skid.
The Giants (4-9) won for the first time since Oct. 5 with two rookies having big games. Odell Beckham Jr. set a team rookie record with his fourth game with 100 yards receiving this season: 11 catches for 130 yards and a TD. Andre Williams ran for a season-high 131 yards, including a 50-yard TD.
Tennessee (2-11) lost its seventh straight and for the 11th time in 12 games with a performance that had fans booing and even a handful wearing paper bags over their heads. This is the franchise's longest skid since losing 11 straight in 1994 as the then-Houston Oilers.
St. Louis recorded back-to-back shutouts for the first time since 1945 en route to picking up its first winning streak of the season.
The Rams sacked Colt McCoy six times. He suffered a neck injury on the sixth sack just before the two-minute warning, so Robert Griffin III finished the game in his first appearance since getting benched two weeks ago. Griffin was sacked once during his brief appearance.
The Redskins (3-10) dropped their fifth straight.
After forcing the Jets to punt to start the extra period, the Vikings faced third-and-5. Bridgewater was blitzed and threw high on a bubble screen pass to his right. Wright jumped for the off-balance grab, slipped by Jaiquawn Jarrett and outran defensive tackle Sheldon Richardson the rest of the way.
Harvin had a 35-yard touchdown reception and a 47-yard kickoff return while finishing with 124 yards on six catches, but he hurt his ankle late in the fourth quarter and didn't return. This was his first game in Minnesota in more than two years after playing his first 3 1/2 seasons with the Vikings.
Arian Foster ran for 127 yards and a touchdown in the victory for Houston.
The Texans won consecutive games for the first time since Week 2 and kept pace in the muddled AFC wild-card race.
Foster's 1-yard run on the second play of the fourth quarter gave Houston (7-6) a comfortable cushion in what had been a back-and-forth game.
After quarterback Ryan Fitzpatrick got stuffed on third down, the Texans lined up for a field goal before calling time out and deciding to go. Foster started right and looked like he would be stopped for a loss, but he eluded a tackle, cut back the other way and high-stepped into the end zone.
The Jaguars (2-11) led 13-10 at halftime, but did little after the break.